NESAC/BIO Director David Castner has been awarded a Shared Instrumentation Grant from the National Institutes of Health to purchase a new Ar gas cluster ion source and an upgraded C60 cluster ion source for the existing NESAC/BIO ToF-SIMS instrument. These new ion sources will add significant new ToF-SIMS capabilities to NESAC/BIO, especially for 3-D imaging and molecular depth profiling of biological materials.