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1. Gelb, L. D.; Bakhtiari, L. A.; Walker, A. V., Statistically rigorous analysis of imaging SIMSdata in the presence of detector saturation. Surf. Inter. Anal. 2015, 47, 889-895.

2. Aram, P.; Shen, L. L.; Pugh, J. A.; Vaidyanathan, S.; Kadirkamanathan, V., An efficient TOF-SIMS image analysis with spatial correlation and alternating non-negativity-constrained least squares. Bioinformatics 2015, 31 (5), 753-760.

3. Wehrli, P. M.; Lindberg, E.; Angerer, T. B.; Wold, A. E.; Gottfries, J.; Fletcher, J. S., Maximising the potential for bacterial phenotyping using time-of-flight secondary ion mass spectrometry with multivariate analysis and Tandem Mass Spectrometry. Surf Interface Anal 2014, 46, 173-176.

4. Tyler, B. J., The accuracy and precision of the advanced Poisson dead-time correction and its importance for multivariate analysis of high mass resolution ToF-SIMS data. Surf Interface Anal 2014, 46 (9), 581-590.

5. Tyler, B. J., The accuracy and precision of the advanced Poisson dead-time correction and its importance for multivariate analysis of high mass resolution ToF-SIMS data. Surf Interface Anal 2014, 46 (9), 581-590.

6. Tyler, B. J.; Peterson, R. E., Dead-time correction for time-of-flight secondary-ion mass spectral images: a critical issue in multivariate image analysis. Surf Interface Anal 2013, 45 (1), 475-478.

7. Tentschert, J.; Draude, F.; Jungnickel, H.; Haase, A.; Mantion, A.; Galla, S.; Thunemann, A. F.; Taubert, A.; Luch, A.; Arlinghaus, H. F., TOF-SIMS analysis of cell membrane changes in functional impaired human macrophages upon nanosilver treatment. Surf Interface Anal 2013, 45 (1), 483-485.

8. Race, A. M.; Steven, R. T.; Palmer, A. D.; Styles, I. B.; Bunch, J., Memory Efficient Principal Component Analysis for the Dimensionality Reduction of Large Mass Spectrometry Imaging Datasets. Anal Chem 2013.

9. Perez, J. J.; Flanigan, P. M. t.; Brady, J. J.; Levis, R. J., Classification of smokeless powders using laser electrospray mass spectrometry and offline multivariate statistical analysis. Anal Chem 2013, 85 (1), 296-302.

10. Palmer, A. D.; Bunch, J.; Styles, I. B., Randomized Approximation Methods for the Efficient Compression and Analysis of Hyperspectral Data. Anal Chem 2013, 85 (10), 5078-5086.

11. Graham, D. J.; Castner, D. G., Image and Spectral Processing for ToF-SIMS Analysis of Biological Materials. Mass Spectrom (Tokyo) 2013, 2 (Spec Iss), S0014.

12. Foster, R. N.; Keefe, A. J.; Jiang, S. Y.; Castner, D. G., Surface initiated atom transfer radical polymerization grafting of sodium styrene sulfonate from titanium and silicon substrates. J Vac Sci Technol A 2013, 31 (6).

13. Aoyagi, S.; Kuroda, K.; Takama, R.; Fukushima, K.; Kayano, I.; Mochizuki, S.; Yano, A., Evaluation of white radish sprouts growth influenced by magnetic fields using TOF-SIMS and MCR. Surf Interface Anal 2013, 45, 264-267.

14. Stein, M. J.; Lo, E.; Castner, D. G.; Ratner, B. D., Plasma Pencil Atmospheric Mass Spectrometry Detection of Positive Ions from Micronutrients Emitted from Surfaces. Anal Chem 2012, 84 (3), 1572-1578.

15. Scoutaris, N.; Hook, A. L.; Gellert, P. R.; Roberts, C. J.; Alexander, M. R.; Scurr, D. J., ToF-SIMS analysis of chemical heterogenities in inkjet micro-array printed drug/polymer formulations J Mater Sci - Mater Med 2012, 23, 385-391.

16. Posma, J. M.; Garcia-Perez, I.; De Iorio, M.; Lindon, J. C.; Elliott, P.; Holmes, E.; Ebbels, T. M.; Nicholson, J. K., Subset Optimization by Reference Matching (STORM): An Optimized Statistical Approach for Recovery of Metabolic Biomarker Structural Information from (1)H NMR Spectra of Biofluids. Anal Chem 2012, 84 (24), 10694-701.

17. Pirro, V.; Eberlin, L. S.; Oliveri, P.; Cooks, R. G., Interactive hyperspectral approach for exploring and interpreting DESI-MS images of cancerous and normal tissue sections. Analyst 2012, 137 (10), 2374-2380.

18. Kirwan, G. M.; Johansson, E.; Kleemann, R.; Verheij, E. R.; Wheelock, A. M.; Goto, S.; Trygg, J.; Wheelock, C. E., Building Multivariate Systems Biology Models. Anal Chem 2012, 84 (16), 7064-7071.

19. Kalegowda, Y.; Harmer, S. L., Chemometric and Multivariate Statistical Analysis of Time-of-Flight Secondary Ion Mass Spectrometry Spectra from Complex Cu-Fe Sulfides. Anal Chem 2012, 84 (6), 2754-2760.

20. Graham, D. J.; Castner, D. G., Multivariate Analysis of ToF-SIMS Data from Multicomponent Systems: The Why, When, and How. Biointerphases 2012, 7, 49.

21. Barnes, C. A.; Brison, J.; Robinson, M.; Graham, D. J.; Castner, D. G.; Ratner, B. D., Identifying Individual Cell Types in Heterogeneous Cultures Using Secondary Ion Mass Spectrometry Imaging with C-60 Etching and Multivariate Analysis. Anal Chem 2012, 84 (2), 893-900.

22. Anderton, C. R.; Vaezian, B.; Lou, K.; Frisz, J. F.; Kraft, M. L., Identification of a lipid-related peak set to enhance the interpretation of TOF-SIMS data from model and cellular membranes. Surf Interface Anal 2012, 44 (3), 322-333.

23. Almstrand, A. C.; Josefson, M.; Bredberg, A.; Lausmaa, J.; Sjövall, P.; Larsson, P.; Olin, A. C., TOF-SIMS analysis of exhaled particles from patients with asthma and healthy controls. Eur Resp J 2012, 39 (1), 59-66.

24. Yun, S. J.; Park, J. W.; Choi, I. J.; Kang, B.; Kim, H. K.; Moon, D. W.; Lee, T. G.; Hwang, D., TOFSIMS-P: A Web-Based Platform for Analysis of Large-Scale TOF-SIMS Data. Anal Chem 2011, 83 (24), 9298-9305.

25. Varmuza, K.; Engrand, C.; Filzmoser, P.; Hilchenbach, M.; Kissel, J.; Kruger, H.; Silen, J.; Trieloff, M., Random projection for dimensionality reduction-Applied to time-of-flight secondary ion mass spectrometry data. Anal Chim Acta 2011, 705 (1-2), 48-55.

26. Tyler, B. J.; Takeno, M. M.; Hauch, K. D., Identification and Imaging of 15N labeled cells with ToF-SIMS. Surf Interface Anal 2011, 43 (1-2), 336-339.

27. Szakal, C.; Narayan, K.; Fu, J.; Lefman, J.; Subramaniam, S., Compositional Mapping of the Surface and Interior of Mammalian Cells at Submicrometer Resolution. Anal Chem 2011, 83 (4), 1207-1213.

28. Reindl, W.; Bowen, B. P.; Balamotis, M. A.; Green, J. E.; Northen, T. R., Multivariate analysis of a 3D mass spectral image for examining tissue heterogeneity. Integrative biology : quantitative biosciences from nano to macro 2011, 3 (4), 460-7.

29. Park, J.-W.; Cho, I.-H.; Moon, D. W.; Paek, S.-H.; Lee, T. G., ToF-SIMS and PCA of surface-immobilized antibodies with different orientations. Surf Interface Anal 2011, 43 (1-2), 285-289.

30. Park, J. W.; Cha, M. J.; Shon, H. K.; Kim, S. H.; Lee, T. G.; Moon, D. W.; Hwang, K. C., ToF-SIMS analysis of myocardial infarcted tissue. Surf Interface Anal 2011, 43 (1-2), 350-353.

31. Mains, J.; Wilson, C.; Urquhart, A., ToF-SIMS analysis of ocular tissues reveals biochemical differentiation and drug distribution. Eur J Pharm Biopharm 2011, 79 (2), 328-333.

32. Killian, M. S.; Krebs, H. M.; Schmuki, P., Protein Denaturation Detected by Time-of-Flight Secondary Ion Mass Spectrometry. Langmuir 2011, 27 (12), 7510-7515.

33. Keenan, M. R.; Smentkowski, V. S., Simple statistically based alternatives to MAF for ToF-SIMS spectral image analysis. Surf Interface Anal 2011, 43 (13), 1616-1626.

34. Fletcher, J. S.; Rabbani, S.; Henderson, A.; Lockyer, N. P.; Vickerman, J. C., Three-dimensional mass spectral imaging of HeLa-M cells-sample preparation, data interpretation and visualization. Rapid Commun Mass Spectrom 2011, 25, 925-932.

35. Brito e Abreu, S.; Skinner, W., Predicting the surface chemistry contribution to the flotation recovery of chalcopyrite by ToF-SIMS. Miner Eng 2011, 24 (2), 160-168.

36. Barnes, C. A.; Brison, J.; Michel, R.; Brown, B. N.; Castner, D. G.; Badylak, S. F.; Ratner, B. D., The surface molecular functionality of decellularized extracellular matrices. Biomaterials 2011, 32 (1), 137-143.

37. Yang, L.; Shard, A. G.; Lee, J. L. S.; Ray, S., Predicting the wettability of patterned ITO surface using ToF-SIMS images. Surf Interface Anal 2010, 42 (6-7), 911-915.

38. Yang, J.; Mei, Y.; Hook, A. L.; Taylor, M.; Urquhart, A. J.; Bogatyrev, S. R.; Langer, R.; Anderson, D. G.; Davies, M. C.; Alexander, M. R., Polymer surface functionalities that control human embryoid body cell adhesion revealed by high throughput surface characterization of combinatorial material microarrays. Biomaterials 2010, 31 (34), 8827-8838.

39. Scurr, D. J.; Horlacher, T.; Oberli, M. A.; Werz, D. B.; Kroeck, L.; Bufali, S.; Seeberger, P. H.; Shard, A. G.; Alexander, M. R., Surface Characterization of Carbohydrate Microarrays. Langmuir 2010, 26 (22), 17143-17155.

40. Sarra-Bournet, C.; Poulin, S.; Piyakis, K.; Turgeon, S.; Laroche, G., ToF-SIMS multivariate characterization of surface modification of polymers by N2-H2 atmospheric pressure dielectric barrier discharge. Surf Interface Anal 2010, 42 (2), 102-109.

41. Mishra, G.; McArthur, S. L., Plasma Polymerisation of Maleic Anhydride: Just what are the right deposition conditions? Langmuir 2010, 26 (12), 9645-9658.

42. Mishra, G.; Easton, C. D.; McArthur, S. L., Physical vs Photolithographic Patterning of Plasma Polymers: An Investigation by ToF-SSIMS and Multivariate Analysis. Langmuir 2010, 26 (5), 3720-3730.

43. Mishra, G.; Easton, C. D.; McArthur, S. L., Physical vs Photolithographic Patterning of Plasma Polymers: An Investigation by ToF−SSIMS and Multivariate Analysis. Langmuir 2010, 26 (5), 3720-3730.

44. Miljkovic, M.; Chernenko, T.; Romeo, M. J.; Bird, B.; Matthaus, C.; Diem, M., Label-free imaging of human cells: algorithms for image reconstruction of Raman hyperspectral datasets. Analyst 2010, 135 (8), 2002-2013.

45. Liu, F.; Dubey, M.; Takahashi, H.; Castner, D. G.; Grainger, D. W., Immobilized Antibody Orientation Analysis Using Secondary Ion Mass Spectrometry and Fluorescence Imaging of Affinity-Generated Patterns. Anal Chem 2010, 82 (7), 2947-2958.

46. Kempson, I. M.; Martin, A. L.; Denman, J. A.; French, P. W.; Prestidge, C. A.; Barnes, T. J., Detecting the Presence of Denatured Human Serum Albumin in an Adsorbed Protein Monolayer Using TOF−SIMS. Langmuir 2010, 26 (14), 12075-12080.

47. Jaumot, J.; Tauler, R., MCR-BANDS: A user friendly MATLAB program for the evaluation of rotation ambiguities in Multivariate Curve Resolution. Chemom Intell Lab Sys 2010, 103 (2), 96-107.

48. Denman, J. A.; Skinner, W. M.; Kirkbride, K. P.; Kempson, I. M., Organic and inorganic discrimination of ballpoint pen inks by ToF-SIMS and multivariate statistics. Appl Surf Sci 2010, 256 (7), 2155-2163.

49. Delwiche, S. R.; Reeves, J. B., A Graphical Method to Evaluate Spectral Preprocessing in Multivariate Regression Calibrations: Example with Savitzky-Golay Filters and Partial Least Squares Regression. Appl Spectrosc 2010, 64 (1), 73-82.

50. Brulet, M.; Seyer, A.; Edelman, A.; Brunelle, A.; Fritsch, J.; Ollero, M.; Laprévote, O., Lipid mapping of colonic mucosa by cluster TOF-SIMS imaging and multivariate analysis in cftr knockout mice. J Lipid Res 2010, 51 (10), 3034-3045.

51. Brito e Abreu, S.; Brien, C.; Skinner, W., ToF-SIMS as a New Method to Determine the Contact Angle of Mineral Surfaces. Langmuir 2010, 26 (11), 8122-8130.

52. Bolles, K. M.; Cheng, F.; Burk-Rafel, J.; Dubey, M.; Ratner, D. M., Imaging Analysis of Carbohydrate-Modified Surfaces Using ToF-SIMS and SPRi. Materials 2010, 3 (7), 3948-3964.

53. Walton, J.; Fairley, N., Data scaling for quantitative imaging XPS. Surf Interface Anal 2009, 41 (2), 114-118.

54. Vaidyanathan, S.; Fletcher, J. S.; Jarvis, R. M.; Henderson, A.; Lockyer, N. P.; Goodacre, R.; Vickerman, J. C., Explanatory multivariate analysis of ToF-SIMS spectra for the discrimination of bacterial isolates. Analyst 2009, 134 (11), 2352-2360.

55. Park, J.-W.; Min, H.; Kim, Y.-P.; Kyong Shon, H.; Kim, J.; Moon, D. W.; Lee, T. G., Multivariate analysis of ToF-SIMS data for biological applications. Surf Interface Anal 2009, 41 (8), 694-703.

56. Lloyd, K. G.; Walls, D. J.; Wyre, J. P., Correlating data from multiple surface-specific techniques using multivariate methods: examples and considerations. Surf Interface Anal 2009, 41 (8), 686-693.

57. Lee, J. L. S.; Gilmore, I. S.; Fletcher, I. W.; Seah, M. P., Multivariate image analysis strategies for ToF-SIMS images with topography. Surf Interface Anal 2009, 41 (8), 653-665.

58. Keenan, M. R., Exploiting spatial-domain simplicity in spectral image analysis. Surf Interface Anal 2009, 41 (2), 79-87.

59. Henderson, A.; Fletcher, J. S.; Vickerman, J. C., A comparison of PCA and MAF for ToF-SIMS image interpretation. Surf Interface Anal 2009, 41 (8), 666-674.

60. Gorlitz, L.; Menze, B. H.; Kelm, B. M.; Hamprecht, F. A., Processing spectral data. Surf Interface Anal 2009, 41 (8), 636-644.

61. Dubey, M.; Emoto, K.; Cheng, F.; Gamble, L. J.; Takahashi, H.; Grainger, D. W.; Castner, D. G., Surface Analysis of Photolithographic Patterns using ToF-SIMS and PCA. Surf Interface Anal 2009, 41 (8), 645-652.

62. Deslandes, A.; Jasieniak, M.; Ionescu, M.; Shapter, J. G.; Fairman, C.; Gooding, J. J.; Hibbert, D. B.; Quinton, J. S., ToFSIMS characterisation of methane and hydrogen plasma modified graphite using principal component analysis. Surf Interface Anal 2009, 41 (3), 216-224.

63. Berman, E. S. F.; Wu, L.; Fortson, S. L.; Kulp, K. S.; Nelson, D. O.; Wu, K. J., Chemometric and statistical analyses of ToF-SIMS spectra of increasingly complex biological samples. Surf Interface Anal 2009, 41 (2), 97-104.

64. Wagner, M. S., Towards quantitative chemical imaging with ToF-SIMS. Appl Surf Sci 2008, 255 (4), 992-996.

65. Vaidyanathan, S.; Fletcher, J. S.; Henderson, A.; Lockyer, N. P.; Vickerman, J. C., Exploratory analysis of TOF-SIMS data from biological surfaces. Appl Surf Sci 2008, 255 (4), 1599-1602.

66. Urquhart, A. J.; Taylor, M.; Anderson, D. G.; Langer, R.; Davies, M. C.; Alexander, M. R., TOF-SIMS analysis of a 576 micropatterned copolymer array to reveal surface moieties that control wettability. Anal Chem 2008, 80 (1), 135-142.

67. Smentkowski, V. S.; Ostrowski, S. G.; Kollmer, F.; Schnieders, A.; Keenan, M. R.; Ohlhausen, J. A.; Kotula, P. G., Multivariate statistical analysis of non-mass-selected ToF-SIMS data. Surf Interface Anal 2008, 40 (8), 1176-1182.

68. Miyasaka, T.; Ikemoto, T.; Kohno, T., ToF-SIMS imaging of PE/PP polymer using multivariate analysis. Appl Surf Sci 2008, 255 (4), 1576-1579.

69. Lee, J. L. S.; Gilmore, I. S.; Seah, M. P., Quantification and methodology issues in multivariate analysis of ToF-SIMS data for mixed organic systems. Surf Interface Anal 2008, 40 (4), 1-14.

70. Kono, T.; Iwase, E.; Kanamori, Y., TOF-SIMS analysis of polystyrene/polybutadiene blend using chemical derivatization and multivariate analysis. Appl Surf Sci 2008, 255 (4), 997-1000.

71. Keenan, M. R.; Smentkowski, V. S.; Ohlhausen, J. A.; Kotula, P. G., Mitigating dead-time effects during multivariate analysis of ToF-SIMS spectral images. Surf Interface Anal 2008, 40 (2), 97-106.

72. Brewer, L. N.; Ohlhausen, J. A.; Kotula, P. G.; Michael, J. R., Forensic analysis of bioagents by X-ray and TOF-SIMS hyperspectral imaging. Forensic Sci Int 2008, 179 (2-3), 98-106.

73. Boden, I.; Nilsson, D.; Naredi, P.; Lindholm-Sethson, B., Characterization of healthy skin using near infrared spectroscopy and skin impedance. Med Biol Eng Comput 2008, 46 (10), 985-995.

74. Bernsmann, F.; Lawrence, N.; Hannig, M.; Ziegler, C.; Gnaser, H., Protein films adsorbed on experimental dental materials: ToF-SIMS with multivariate data analysis. Anal Bioanal Chem 2008, 391 (2), 545-554.

75. Berman, E. S. F.; Wu, L.; Fortson, S. L.; Kulp, K. S.; Nelson, D. O.; Wu, K. J., Chemometric and statistical analyses of ToF-SIMS spectra of increasingly complex biological samples. Surf Interface Anal 2008, 41, 97-104.

76. Baker, M. J.; Gazi, E.; Brown, M. D.; Clarke, N. W.; Vickerman, J. C.; Lockyer, N. P., ToF-SIMS PC-DFA analysis of prostate cancer cell lines. Appl Surf Sci 2008, 255 (4), 1084-1087.

77. Tyler, B. J.; Rayal, G.; Castner, D. G., Multivariate analysis strategies for processing ToF-SIMS images of biomaterials. Biomaterials 2007, 28 (15), 2412-2423.

78. Smentkowski, V. S.; Ostrowski, S. G.; Braunstein, E.; Keenan, M. R.; Ohlhausen, J. A.; Kotula, P. G., Multivariate Statistical Analysis of Three-Spatial-Dimension TOF-SIMS Raw Data Sets. Anal Chem 2007, 79 (20), 7719-7726.

79. Smentkowski, V. S.; Ostrowski, S. G., Time of flight secondary ion mass spectrometry: A powerful high throughput screening tool. Rev Sci Instrum 2007, 78 (7).

80. Rodriguez-Rodriguez, C.; Amigo, J. M.; Coello, J.; Maspoch, S., An Introduction to Multivariate Curve Resolution-Alternating Least Squares: Spectrophotometric Study of the Acid-Base Equilibria of 8-Hydroxyquinoline-5-sulfonic Acid. J. Chem Ed. 2007, 84, 1190.

81. Lloyd, K. G., Application of multivariate statistical analysis methods for improved time-of-flight secondary ion mass spectrometry depth profiling of buried interfaces and particulate. J Vac Sci Technol A 2007, 25 (4), 878-885.

82. Klerk, L. A.; Broersen, A.; Fletcher, I. W.; van Liere, R.; Heeren, R. M. A., Extended data analysis strategies for high resolution imaging MS: New methods to deal with extremely large image hyperspectral datasets. Int J Mass Spec 2007, 260 (2–3), 222-236.

83. Tyler, B. J.; Rangaranjan, S.; Moller, J.; Beumer, A.; Arlinghaus, H. E., TOF-SIMS imaging of chlorhexidine-digluconate transport in frozen hydrated biofilms of the fungus Candida albicans. Appl Surf Sci 2006, 252 (19), 6712-6715.

84. Tyler, B. J., Multivariate statistical image processing for molecular specific imaging in organic and bio-systems. Appl Surf Sci 2006, 252 (19), 6875-6882.

85. Thompson, C. E.; Ellis, J.; Fletcher, J. S.; Goodacre, R.; Henderson, A.; Lockyer, N. P.; Vickerman, J. C., ToF-SIMS studies of Bacillus using multivariate analysis with possible identification and taxonomic applications. Appl Surf Sci 2006, 252 (19), 6719-6722.

86. Michel, R.; Castner, D. G., Advances in time-of-flight secondary ion mass spectrometry analysis of protein films. Surf Interface Anal 2006, 38 (11), 1386-1392.

87. Graham, D. J.; Wagner, M. S.; Castner, D. G., Information from complexity: Challenges of TOF-SIMS data interpretation. Appl Surf Sci 2006, 252 (19), 6860-6868.

88. Fletcher, J. S.; Henderson, A.; Jarvis, R. M.; Lockyer, N. P.; Vickerman, J. C.; Goodacre, R., Rapid discrimination of the casual agents of urinary tract infection using ToF-SIMS with chemometrics cluster analysis. Appl Surf Sci 2006, 252 (19), 6869-6874.

89. Berman, E. S. F.; Kulp, K. S.; Knize, M. G.; Wu, L. G.; Nelson, E. J.; Nelson, D. O.; Wu, K. J., Distinguishing monosaccharide stereo- and structural isomers with TOF-SIMS and multivariate statistical analysis. Anal Chem 2006, 78 (18), 6497-6503.

90. Yang, L.; Lua, Y.-Y.; Jiang, G.; Tyler, B. J.; Linford, M. R., Multivariate analysis of TOF-SIMS spectra of monolayers on scribed silicon. Anal Chem 2005, 77 (14), 4654-4661.

91. von Gradowski, M.; Jacoby, B.; Hilgers, H.; Barz, J.; Wahl, M.; Kopnarski, M., ToF-SIMS characterisation of ultra-thin fluorinated carbon plasma polymer films. Surf Coat Tech 2005, 200 (1–4), 334-340.

92. Verboven, S.; Hubert, M., LIBRA: a MATLAB library for robust analysis. Chemom Intell Lab Sys 2005, 75 (2), 127-136.

93. Lavine, B. K.; Workman, J., Chemometrics: Past, present, and future. Acs Sym Ser 2005, 894, 1-13.

94. Lavine, B. K.; Workman, J., Chemometrics: Past, Present, and Future. In ACS Symposium Series, 2005; pp 1-13.

95. Jaumot, J.; Gargallo, R.; de Juan, A.; Tauler, R., A graphical user-friendly interface for MCR-ALS: a new tool for multivariate curve resolution in MATLAB. Chemom Intell Lab Sys 2005, 76 (1), 101-110.

96. Hubert, M.; Rousseeuw, P. J.; Vanden Branden, K., ROBPCA: A new approach to robust principal component analysis. Technometrics 2005, 47 (1), 64-79.

97. Brys, G.; Hubert, M.; Rousseeuw, P. J., A robustification of independent component analysis. J Chemom 2005, 19 (5-7), 364-375.

98. Wang, H.; Castner, D. G.; Ratner, B. D.; Jiang, S. Y., Probing the orientation of surface-immobilized immunoglobulin G by time-of-flight secondary ion mass spectrometry. Langmuir 2004, 20 (5), 1877-1887.

99. Wagner, M. S.; Pasche, S.; Castner, D. G.; Textor, M., Characterization of poly(L-iysine)-graft-poly(ethylene glycol) assembled monolayers on niobium pentoxide substrates using time-of-flight secondary ion mass spectrometry and multivariate analysis. Anal Chem 2004, 76 (5), 1483-1492.

100. Wagner, M. S.; Graham, D. J.; Ratner, B. D.; Castner, D. G., Maximizing information obtained from secondary ion mass spectra of organic thin films using multivariate analysis. Surf Sci 2004, 570 (1-2), 78-97.

101. Steven J, P., Enhancing and automating TOF-SIMS data interpretation using principal component analysis. Appl Surf Sci 2004, 231–232 (0), 217-223.

102. Smentkowski, V. S.; Ohlhausen, J. A.; Kotula, P. G.; Keenan, M. R., Multivariate statistical analysis of time-of-flight secondary ion mass spectrometry images-looking beyond the obvious. Appl Surf Sci 2004, 231, 245-249.

103. Rangarajan, S.; Tyler, B. J., Interpretation of static time-of-flight ion mass spectral images of adsorbed protein films on topographically complex surfaces. Appl Surf Sci 2004, 231–232, 406-410.

104. Michaeleen L, P., Principal component analysis of TOF-SIMS spectra, images and depth profiles: an industrial perspective. Appl Surf Sci 2004, 231–232, 235-239.

105. May, C. J.; Canavan, H. E.; Castner, D. G., Quantitative X-ray Photoelectron Spectroscopy and Time-of-Flight Secondary Ion Mass Spectrometry Characterization of the Components in DNA. Anal Chem 2004, 76, 1114-1122.

106. Keenan, M. R.; Kotula, P. G., Optimal scaling of TOF-SIMS spectrum-images prior to multivariate statistical analysis. Appl Surf Sci 2004, 231, 240-244.

107. Keenan, M. R.; Kotula, P. G., Accounting for Poisson noise in the multivariate analysis of ToF-SIMS spectrum images. Surf Interface Anal 2004, 36 (3), 203-212.

108. Gallagher, N. B.; Shaver, J. M.; Martin, E. B.; Morris, J.; Wise, B. M.; Windig, W., Curve resolution for multivariate images with applications to TOF-SIMS and Raman. Chemom Intell Lab Sys 2004, 73 (1), 105-117.

109. de Juan, A.; Tauler, R.; Dyson, R.; Marcolli, C.; Rault, M.; Maeder, M., Spectroscopic imaging and chemometrics: a powerful combination for global and local sample analysis. Trac-Trend Anal Chem 2004, 23 (1), 70-79.

110. Auditore, A.; Tuccitto, N.; Quici, S.; Marzanni, G.; Puntoriero, F.; Campagna, S.; Licciardello, A., ToF-SIMS investigation of functional mixed aromatic thiol monolayers on gold. Appl Surf Sci 2004, 231, 314-317.

111. Wickes, B. T.; Kim, Y.; Castner, D. G., Denoising and multivariate analysis of time-of-flight SIMS images. Surf Interface Anal 2003, 35 (8), 640-648.

112. Wagner, M. S.; Shen, M.; Horbett, T. A.; Castner, D. G., Quantitative analysis of binary adsorbed protein films by time of flight secondary ion mass spectrometry. J Biomed Mater Res A 2003, 64 (1), 1-11.

113. Wagner, M. S.; Shen, M.; Horbett, T. A.; Castner, D. G., Quantitative time-of-flight secondary ion mass spectrometry for the characterization of multicomponent adsorbed protein films. Appl Surf Sci 2003, 203–204, 704-709.

114. Wagner, M. S.; Castner, D. G., Characterization of adsorbed protein films using time-of-flight-secondary ion mass spectrometry and multivariate analysis. Appl Surf Sci 2003, 203-204, 698-703.

115. Tyler, B., Interpretation of TOF-SIMS images: multivariate and univariate approaches to image de-noising, image segmentation and compound identification. Appl Surf Sci 2003, 203–204, 825-831.

116. Shen, M.; Wagner, M. S.; Castner, D. G.; Ratner, B. D.; Horbett, T. A., Multivariate Surface Analysis of Plasma-Deposited Tetraglyme for Reduction of Protein Adsorption and Monocyte Adhesion. Langmuir 2003, 19 (5), 1692-1699.

117. Peterson, R. E.; Tyler, B. J., Surface composition of atmospheric aerosol: individual particle characterization by TOF-SIMS. Appl Surf Sci 2003, 203-204, 751-756.

118. Médard, N.; Benninghoven, A.; Rading, D.; Licciardello, A.; Auditore, A.; Duc, T. M.; Montigaud, H.; Vernerey, F.; Poleunis, C.; Bertrand, P., Antioxidant segregation and crystallisation at polyester surfaces studied by ToF-SIMS. Appl Surf Sci 2003, 203-204, 571-574.

119. Ingram, J. C.; Bauer, W. F.; Lehman, R. M.; O'Connell, S. P.; Shaw, A. D., Detection of fatty acids from intact microorganisms by molecular beam static secondary ion mass spectrometry. J Microbiol Methods 2003, 53 (3), 295-307.

120. Geladi, P., Chemometrics in spectroscopy. Part 1. Classical chemometrics. Spectrochimica Acta Part B 2003, 58, 767-782.

121. de Juan, A.; Tauler, R., Chemometrics applied to unravel multicomponent processes and mixtures - Revisiting latest trends in multivariate resolution. Anal Chim Acta 2003, 500 (1-2), 195-210.

122. Coullerez, G.; Lundmark, S.; Malmström, E.; Hult, A.; Mathieu, H. J., ToF-SIMS for the characterization of hyperbranched aliphatic polyesters: probing their molecular weight on surfaces based on principal component analysis (PCA). Surf Interface Anal 2003, 35 (8), 693-708.

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